Full Name:
Alternative Names:
ANK, SPH1, SPH2, ANK1, Ankyrin-R
Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.Isoform Mu17 together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
Death Domain Subfamily & Boundary Region:
  • DD : 1403-1487 Seq
Species External DB Questionmark
Human Seq P16157external db link P16157external db link hsa:286external db link P16157external db link MINT-254860external db link
Mouse Seq Q02357external db link Q02357external db link mmu:11733external db link MINT-255055external db link
Rat Seq F1MA94external db link
Dog Seq F1PRC7external db link
Structure Species Residue Method Expression Purification Column Final condition Final concentration Reference
2YVI Download Human X-ray
2YQF Download Human NMR
Disease Mutation in disease Reference
Spherocytosis 1486040
Spherocytosis E1669X 7883994
Spherocytosis W1721X, R1833X 9590147
Spherocytosis 9887280
Spherocytosis H276R, I1054T 11102985
Spherocytosis 169fs 11167760
Spherocytosis 17327413
Question There is no death-domain PPI with ANK1 in Death Domain DD subfamily.