DR6 (DD)

Full Name:
Tumor necrosis factor receptor superfamily member 21
Alternative Names:
BM-018, MGC31965, TNFRSF21
May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
Death Domain Subfamily & Boundary Region:
  • DD : 415-498 Seq
Species External DB Questionmark
Human Seq O75509external db link DIP-53299Nexternal db link O75509external db link hsa:27242external db link O75509external db link
Mouse Seq Q9EPU5external db link Q9EPU5external db link mmu:94185external db link
Rat Seq D3ZF92external db link rno:316256external db link
Dog Seq F1PUV8external db link
Zebra fish Seq A5D8S6external db link dre:564874external db link
Not solved yet
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD DR6 Link TRADD Co-immunoprecipitation HEK293 Not specified 42-655 Not specified Not specified 9714541
(Link: click this icon to show interactions only between the two corresponding DDs)