MDA5 (CARD)
- At a glance
- In detail
- Full Name:
- Interferon-induced helicase C domain-containing protein 1
- Alternative Names:
- Hlcd, IFIH1, MDA-5, IDDM19, MGC133047
- Function:
- RNA helicase that, through its ATP-dependent unwinding of RNA, may function to promote message degradation by specific RNases. Seems to have growth suppressive properties. Involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). ATPase activity is specifically induced by dsRNA. Essential for the production of interferons in response to picornaviruses.
- Death Domain Subfamily & Boundary Region:
-
CARD
:
7-97, 110-190
Species |
External DB
![]() |
||||||
---|---|---|---|---|---|---|---|
Uniprot | DIP | STRING | KEGG | IntAct | MINT | ||
Human |
![]() |
Q9BYX4![]() |
DIP-42607N![]() |
Q9BYX4![]() |
hsa:64135![]() |
MINT-3381993![]() |
|
Mouse |
![]() |
Q8R5F7![]() |
Q8R5F7![]() |
mmu:71586![]() |
|||
Rat |
![]() |
B5DEI3![]() |
B5DEI3![]() |
||||
Dog |
![]() |
E2RNK0![]() |
Not solved yet
No information
![]() ![]() ![]() ![]() |
![]() |
In vivo interaction | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Endogenous expression |
Overexpression | DD1 | DD2 | Reference | |||||||||
Family | DD1 | DD2 | Method | Species | Region | Species | Region | ||||||
CARD | MDA5 |
![]() |
MAVS | Co-immunoprecipitation | HEK293 | Human | 1-575 | Human | Not specified | 16127453 | |||
CARD | MDA5 |
![]() |
RIG-1 | Co-immunoprecipitation | HEK293 | Not specified | Not specified | Not specified | Not specified | 22328336 |
(
: click this icon to show interactions only between the two corresponding DDs)

![]() ![]() ![]() ![]() |
![]() |
Functional Role | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Family | DD1 | DD2 | Method | Death-related | Death-unrelated | Reference | |||||
CARD | MDA5 |
![]() |
MAVS | ELISA | Type 1 interferon induced | 16127453 |
(
: click this icon to show interactions only between the two corresponding DDs)
