MDA5 (CARD)

Full Name:
Interferon-induced helicase C domain-containing protein 1
Alternative Names:
Hlcd, IFIH1, MDA-5, IDDM19, MGC133047
Function:
RNA helicase that, through its ATP-dependent unwinding of RNA, may function to promote message degradation by specific RNases. Seems to have growth suppressive properties. Involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). ATPase activity is specifically induced by dsRNA. Essential for the production of interferons in response to picornaviruses.
Death Domain Subfamily & Boundary Region:
  • CARD : 7-97, 110-190 Seq
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q9BYX4external db link DIP-42607Nexternal db link Q9BYX4external db link hsa:64135external db link MINT-3381993external db link
Mouse Seq Q8R5F7external db link Q8R5F7external db link mmu:71586external db link
Rat Seq B5DEI3external db link B5DEI3external db link
Dog Seq E2RNK0external db link
Not solved yet
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression		 Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD MDA5 Link MAVS Co-immunoprecipitation HEK293 Human 1-575 Human Not specified 16127453
CARD MDA5 Link RIG-1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 22328336
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD MDA5 Link MAVS ELISA Type 1 interferon induced 16127453
(Link: click this icon to show interactions only between the two corresponding DDs)
  » Citation