RAIDD (DD)
- At a glance
- In detail
- Full Name:
- Death domain-containing protein CRADD
- Alternative Names:
- MGC9163, CRADD
- Function:
- Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.
- Death Domain Subfamily & Boundary Region:
Species |
External DB
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Uniprot | DIP | STRING | KEGG | IntAct | MINT | ||
Human |
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P78560![]() |
DIP-34550N![]() |
P78560![]() |
hsa:8738![]() |
P78560![]() |
MINT-1520976![]() |
Mouse |
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O88843![]() |
O88843![]() |
mmu:12905![]() |
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Rat |
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D3ZB14![]() |
DIP-48601N![]() |
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Dog |
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E2R247![]() |
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Zebra fish |
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Q5XJP2![]() |
Q5XJP2![]() |
dre:450046![]() |
Structure | Species | Residue | Method | Expression | Purification | Column | Final condition | Final concentration | Reference | |
---|---|---|---|---|---|---|---|---|---|---|
2O71 |
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Human | 109-199 | X-ray | E.coli | Gel filtration | 6mg/ml | 16434054 | ||
2OF5 |
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Human | 94-199 | X-ray | E.coli | Gel filtration | Superdex 200 | 12mg/ml | 17289572 |
No information
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In vitro interaction | |||||||||||||
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DD1 | DD2 | Reference | |||||||||||
Family | DD1 | DD2 | Method | Species | Region | Expression | Species | Region | Expression | ||||
DD | RAIDD |
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PIDD | In vitro purification protein assembly(Native gel-electrophoresis) | Human | 94-199 | E.coli | Human | 777-883 | E.coli | 20406701 | ||
DD | RAIDD |
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PIDD | In vitro purification protein assembly(Native gel-electrophoresis) | Human | Full length | E.coli | Human | 777-883 | E.coli | 20872280 | ||
DD | RAIDD |
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PIDD | In vitro purification protein assembly(Size-exclusion chromatography) | Not specified | 101-199 | HEK293 | Not specified | Full length | HEK293 | 15073321 | ||
DD | RAIDD |
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PIDD | In vitro purification protein assembly(Size-exclusion chromatography) | Human | 94-199 | E.coli | Human | 777-883 | E.coli | 17289572 | ||
DD | RAIDD |
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PIDD | In vitro purification protein assembly(Size-exclusion chromatography) | Human | 94-199 | E.coli | Human | 777-883 | E.coli | 17329820 | ||
DD | RAIDD |
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PIDD | In vitro purification protein assembly(Size-exclusion chromatography) | Human | 94-199 | E.coli | Human | 777-883 | E.coli | 20406701 | ||
DD | RAIDD |
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PIDD | In vitro purification protein assembly(Size-exclusion chromatography) | Human | Full length | E.coli | Human | 777-883 | E.coli | 20872280 | ||
DD | RAIDD |
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RIP | GST fusion protein pull-down | Human | Not specified | E.coli | Human | Not specified | In vitro translation | 9044836 |
(
: click this icon to show interactions only between the two corresponding DDs)

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In vivo interaction | |||||||||||||
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Endogenous expression |
Overexpression | DD1 | DD2 | Reference | |||||||||
Family | DD1 | DD2 | Method | Species | Region | Species | Region | ||||||
DD | RAIDD |
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PIDD | Co-Immunofluorescence staining | HCT116 | 16652156 | |||||||
DD | RAIDD |
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PIDD | Co-immunoprecipitation | HEK293 | Not specified | 101-199 | Not specified | Full length | 15073321 | |||
DD | RAIDD |
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PIDD | Co-immunoprecipitation | Jurkat | Not used | Not specified | Not specified | 16360037 | ||||
DD | RAIDD |
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PIDD | Co-immunoprecipitation | HCT116 | 16652156 | |||||||
DD | RAIDD |
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PIDD | Co-immunoprecipitation | HEK293 | Not specified | Not specified | Not specified | 588-910 | 17159900 | |||
DD | RAIDD |
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PIDD | Co-immunoprecipitation | HEK293 | Human | 94-199 | Not specified | 777-883 | 17289572 | |||
DD | RAIDD |
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PIDD | Co-immunoprecipitation | Hippocampal CA1 subregion | 18845684 | |||||||
DD | RAIDD |
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PIDD | Co-immunoprecipitation | HEK293 | Not used | Not specified | Not specified | 20966961 | ||||
DD | RAIDD |
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PIDD | Size-exclusion chromatography | HEK293 | Not used | Not specified | Not specified | 20966961 | ||||
DD | RAIDD |
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RIP | Co-immunoprecipitation | Mouse brain cell | 11978827 |
(
: click this icon to show interactions only between the two corresponding DDs)

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Characterization | |||||||||||
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Stoichiometry | Affinity | Protein-Protein interface | Reference | ||||||||
Family | DD1 | DD2 | Method | Mutation | Complex structure | ||||||
DD | RAIDD |
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PIDD | Gel filtration | 5:7 | 2OF5 | 17289572 | ||||
DD | RAIDD |
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PIDD | Gel filtration | 7:5 | 2OF5 | 17289572 | ||||
DD | RAIDD |
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PIDD | Gel filtration | 5:7 | 20872280 | |||||
DD | RAIDD |
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PIDD | Gel filtration | 7:5 | 20872280 |
(
: click this icon to show interactions only between the two corresponding DDs)

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Functional Role | |||||||||||
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Family | DD1 | DD2 | Method | Death-related | Death-unrelated | Reference | |||||
DD | RAIDD |
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PIDD | Trypan blue staining | Apoptosis (PIDDosome) | 15073321 | |||||
DD | RAIDD |
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PIDD | Caspase cleaved assay | Caspase2 activation (PIDDosome) | 17159900 | |||||
DD | RAIDD |
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PIDD | TUNEL assay | Apoptosis (PIDDosome) | 18845684 |
(
: click this icon to show interactions only between the two corresponding DDs)
