UNC5B (DD)
- At a glance
- In detail
- Full Name:
- Netrin receptor UNC5B
- Alternative Names:
- UNC5H2, p53RDL1
- Function:
- Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
- Death Domain Subfamily & Boundary Region:
-
DD
:
865-943
Species |
External DB
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Uniprot | DIP | STRING | KEGG | IntAct | MINT | ||
Human |
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Q8IZJ1![]() |
DIP-46275N![]() |
Q8IZJ1![]() |
hsa:219699![]() |
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Mouse |
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Q8K1S3![]() |
Q8K1S3![]() |
mmu:107449![]() |
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Rat |
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O08722![]() |
O08722![]() |
rno:60630![]() |
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Dog |
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E2RC29![]() |
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Zebra fish |
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A3KPR8![]() |
Structure | Species | Residue | Method | Expression | Purification | Column | Final condition | Final concentration | Reference | |
---|---|---|---|---|---|---|---|---|---|---|
1WMG |
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Mouse | 854-943 | X-ray | 17139086 | |||||
3G5B |
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Rat | 543-943 | X-ray | E.coli | Gel filtration | Superose 12 | 50mM tris-HCl(pH7.5), 100mM NaCl, 1mM DTT | 19328064 |
No information
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In vivo interaction | |||||||||||||
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Endogenous expression |
Overexpression | DD1 | DD2 | Reference | |||||||||
Family | DD1 | DD2 | Method | Species | Region | Species | Region | ||||||
DD | UNC5B |
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DAPK1 | Co-immunoprecipitation | HEK293 | Not specified | Full length | Not specified | Full length | 15729359 | |||
DD | UNC5B |
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DAPK1 | Co-immunoprecipitation | HEK293 | Not specified | Not specified | Not specified | Full length | 15729359 | |||
DD | UNC5B |
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DAPK1 | Co-immunoprecipitation | HEK293 | Not specified | 841-945 | Not specified | Full length | 15729359 | |||
DD | UNC5B |
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DAPK1 | Co-immunoprecipitation | HEK293 | Not specified | 631-945 | Not specified | Full length | 15729359 | |||
DD | UNC5B |
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DAPK1 | Co-immunoprecipitation | HEK293 | Not specified | Full length | Not specified | 1301-1431 | 15729359 |
(
: click this icon to show interactions only between the two corresponding DDs)

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Functional Role | |||||||||||
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Family | DD1 | DD2 | Method | Death-related | Death-unrelated | Reference | |||||
DD | UNC5B |
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DAPK1 | Trypan blue staining, Immunoprecipitation | Apoptosis, DAPK kinase activity increase | 15729359 |
(
: click this icon to show interactions only between the two corresponding DDs)
