Curated Publications

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PMID Title Authors Journal Year
23066025 Multiple binding sites on the ASC pyrin domain allow self-association and interaction with NLRP3. External Vajjhala, P. R., Mirams, R. E., Hill, J. M. J Biol Chem 2012
22922561 Formation of the death domain complex between FADD and RIP1 proteins in vitro. External Park, Y. H., Jeong, M. S., Park, H. H., Jang, S. B. Biochim Biophys Acta 2012
22890322 RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/FADD/caspase-8 cell death complex. External Abhari, B. A., Cristofanon, S., Kappler, R., von Schweinitz, D., Humphreys, R., Fulda, S. Oncogene 2012
22880103 Structural insights into the assembly of CARMA1 and BCL10. External Li, S., Yang, X., Shao, J., Shen, Y. PLoS One 2012
22869553 Interactome-wide Analysis Identifies End-binding Protein 1 as a Crucial Component for the Speck-like Particle Formation of Activated Absence in Melanoma 2 (AIM2) Inflammasomes. External Wang, L. J., Hsu, C. W., Chen, C. C., Liang, Y., Chen, L. C., Ojcius, D. M., Tsang, N. M., Hsueh, C., Wu, C. C., Chang, Y. S. Mol Cell Proteomics 2012
22665475 A dual role for receptor-interacting protein kinase 2 (RIP2) kinase activity in nucleotide-binding oligomerization domain 2 (NOD2)-dependent autophagy. External Homer, C. R., Kabi, A., Marina-Garcia, N., Sreekumar, A., Nesvizhskii, A. I., Nickerson, K. P., Chinnaiyan, A. M., Nunez, G., McDonald, C. J Biol Chem 2012
22515271 Neuronal caspase 2 activity and function requires RAIDD, but not PIDD. External Ribe, E. M., Jean, Y. Y., Goldstein, R. L., Manzl, C., Stefanis, L., Villunger, A., Troy, C. M. Biochem J 2012
22470564 The tandem CARDs of NOD2: intramolecular interactions and recognition of RIP2. External Fridh, V., Rittinger, K. PLoS One 2012
22361007 An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages. External Khare, S., Dorfleutner, A., Bryan, N. B., Yun, C., Radian, A. D., de Almeida, L., Rojanasakul, Y., Stehlik, C. Immunity 2012
22328336 Ankrd17 positively regulates RIG-I-like receptor (RLR)-mediated immune signaling. External Wang, Y., Tong, X., Li, G., Li, J., Deng, M., Ye, X. Eur J Immunol 2012
22323537 Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes. External Lin, Q., Liu, Y., Moore, D. J., Elizer, S. K., Veach, R. A., Hawiger, J., Ruley, H. E. J Immunol 2012
22179576 Hsp27 silencing coordinately inhibits proliferation and promotes Fas-induced apoptosis by regulating the PEA-15 molecular switch. External Hayashi, N., Peacock, J. W., Beraldi, E., Zoubeidi, A., Gleave, M. E., Ong, C. J. Cell Death Differ 2012
21994322 Hepatitis C virus activates interleukin-1beta via caspase-1-inflammasome complex. External Burdette, D., Haskett, A., Presser, L., McRae, S., Iqbal, J., Waris, G. J Gen Virol 2012
21931591 cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). External Bertrand, M. J., Lippens, S., Staes, A., Gilbert, B., Roelandt, R., De Medts, J., Gevaert, K., Declercq, W., Vandenabeele, P. PLoS One 2011
21862576 Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor kappaB signaling. External Kersse, K., Lamkanfi, M., Bertrand, M. J., Vanden Berghe, T., Vandenabeele, P. J Biol Chem 2011
21760970 Suppression of TNF receptor-1 signaling in an in vitro model of epileptic tolerance. External Thompson, S. J., Ashley, M. D., Stohr, S., Schindler, C., Li, M., McCarthy-Culpepper, K. A., Pearson, A. N., Xiong, Z. G., Simon, R. P., Henshall, D. C., Meller, R. Int J Physiol Pathophysiol Pharmacol 2011
21741934 Characterization of DISC formation and TNFR1 translocation to mitochondria in TNF-alpha-treated hepatocytes. External Eum, H. A., Vallabhaneni, R., Wang, Y., Loughran, P. A., Stolz, D. B., Billiar, T. R. Am J Pathol 2011
21690088 Retinoic acid-induced gene-I (RIG-I) associates with nucleotide-binding oligomerization domain-2 (NOD2) to negatively regulate inflammatory signaling. External Morosky, S. A., Zhu, J., Mukherjee, A., Sarkar, S. N., Coyne, C. B. J Biol Chem 2011
21575908 IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection. External Kerur, N., Veettil, M. V., Sharma-Walia, N., Bottero, V., Sadagopan, S., Otageri, P., Chandran, B. Cell Host Microbe 2011
21557211 Actin-independent exclusion of CD95 by PI3K/AKT signalling: implications for apoptosis. External Pizon, M., Rampanarivo, H., Tauzin, S., Chaigne-Delalande, B., Daburon, S., Castroviejo, M., Moreau, P., Moreau, J. F., Legembre, P. Eur J Immunol 2011
21525013 TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8. External Ikner, A., Ashkenazi, A. J Biol Chem 2011
21419663 RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein. External Rajput, A., Kovalenko, A., Bogdanov, K., Yang, S. H., Kang, T. B., Kim, J. C., Du, J., Wallach, D. Immunity 2011
21272366 Modulation of TRAIL resistance in colon carcinoma cells: different contributions of DR4 and DR5. External van Geelen, C. M., Pennarun, B., Le, P. T., de Vries, E. G., de Jong, S. BMC Cancer 2011
21252346 Discovery of a viral NLR homolog that inhibits the inflammasome. External Gregory, S. M., Davis, B. K., West, J. A., Taxman, D. J., Matsuzawa, S., Reed, J. C., Ting, J. P., Damania, B. Science 2011
21199863 The Ca2+-dependent phosphatase calcineurin controls the formation of the Carma1-Bcl10-Malt1 complex during T cell receptor-induced NF-kappaB activation. External Palkowitsch, L., Marienfeld, U., Brunner, C., Eitelhuber, A., Krappmann, D., Marienfeld, R. B. J Biol Chem 2011
21179087 Oncogenically active MYD88 mutations in human lymphoma. External Ngo, V. N., Young, R. M., Schmitz, R., Jhavar, S., Xiao, W., Lim, K. H., Kohlhammer, H., Xu, W., Yang, Y., Zhao, H., Shaffer, A. L., Romesser, P., Wright, G., Powell, J., Rosenwald, A., Muller-Hermelink, H. K., Ott, G., Gascoyne, R. D., Connors, J. M., Rimsza, L. M., Campo, E., Jaffe, E. S., Delabie, J., Smeland, E. B., Fisher, R. I., Braziel, R. M., Tubbs, R. R., Cook, J. R., Weisenburger, D. D., Chan, W. C., Staudt, L. M. Nature 2011
21168190 Tissue Factor/ FVIIa prevents the extrinsic pathway of apoptosis by regulation of the tumor suppressor Death-Associated Protein Kinase 1 (DAPK1). External Aberg, M., Johnell, M., Wickstrom, M., Siegbahn, A. Thromb Res 2011
21157432 Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation. External Eitelhuber, A. C., Warth, S., Schimmack, G., Duwel, M., Hadian, K., Demski, K., Beisker, W., Shinohara, H., Kurosaki, T., Heissmeyer, V., Krappmann, D. EMBO J 2011
21131052 Recombinant YopJ induces apoptotic cell death in macrophages through TLR2. External Pandey, A. K., Sodhi, A. Mol Immunol 2011
21109225 Whole-exome-sequencing-based discovery of human FADD deficiency. External Bolze, A., Byun, M., McDonald, D., Morgan, N. V., Abhyankar, A., Premkumar, L., Puel, A., Bacon, C. M., Rieux-Laucat, F., Pang, K., Britland, A., Abel, L., Cant, A., Maher, E. R., Riedl, S. J., Hambleton, S., Casanova, J. L. Am J Hum Genet 2010
20966961 Regulation of PIDD auto-proteolysis and activity by the molecular chaperone Hsp90. External Tinel, A., Eckert, M. J., Logette, E., Lippens, S., Janssens, S., Jaccard, B., Quadroni, M., Tschopp, J. Cell Death Differ 2011
20966070 Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly. External George, J., Motshwene, P. G., Wang, H., Kubarenko, A. V., Rautanen, A., Mills, T. C., Hill, A. V., Gay, N. J., Weber, A. N. J Biol Chem 2011
20935634 The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. External Wang, L., Yang, J. K., Kabaleeswaran, V., Rice, A. J., Cruz, A. C., Park, A. Y., Yin, Q., Damko, E., Jang, S. B., Raunser, S., Robinson, C. V., Siegel, R. M., Walz, T., Wu, H. Nat Struct Mol Biol 2010
20872280 In vitro reconstitution of the interactions in the PIDDosome. External Jang, T. H., Zheng, C., Wu, H., Jeon, J. H., Park, H. H. Apoptosis 2010
20818395 Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. External Wang, P., Arjona, A., Zhang, Y., Sultana, H., Dai, J., Yang, L., LeBlanc, P. M., Doiron, K., Saleh, M., Fikrig, E. Nat Immunol 2010
20547836 Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression. External Petersen, S. L., Peyton, M., Minna, J. D., Wang, X. Proc Natl Acad Sci U S A 2010
20538615 CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans. External Bi, L., Gojestani, S., Wu, W., Hsu, Y. M., Zhu, J., Ariizumi, K., Lin, X. J Biol Chem 2010
20485341 Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. External Lin, S. C., Lo, Y. C., Wu, H. Nature 2010
20439115 Interaction of calmodulin with Bcl10 modulates NF-kappaB activation. External Edin, S., Oruganti, S. R., Grundstrom, C., Grundstrom, T. Mol Immunol 2010
20406701 Identification and analysis of dominant negative mutants of RAIDD and PIDD. External Jang, T. H., Bae, J. Y., Park, O. K., Kim, J. H., Cho, K. H., Jeon, J. H., Park, H. H. Biochim Biophys Acta 2010
20393137 Anti-inflammatory activity of PYNOD and its mechanism in humans and mice. External Imamura, R., Wang, Y., Kinoshita, T., Suzuki, M., Noda, T., Sagara, J., Taniguchi, S., Okamoto, H., Suda, T. J Immunol 2010
20222921 Mutations in EDARADD account for a small proportion of hypohidrotic ectodermal dysplasia cases. External Chassaing, N., Cluzeau, C., Bal, E., Guigue, P., Vincent, M. C., Viot, G., Ginisty, D., Munnich, A., Smahi, A., Calvas, P. Br J Dermatol 2010
19841089 Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells. External Ferch, U., Kloo, B., Gewies, A., Pfander, V., Duwel, M., Peschel, C., Krappmann, D., Ruland, J. J Exp Med 2009
19782032 Characterization of cytoplasmic caspase-2 activation by induced proximity. External Bouchier-Hayes, L., Oberst, A., McStay, G. P., Connell, S., Tait, S. W., Dillon, C. P., Flanagan, J. M., Beere, H. M., Green, D. R. Mol Cell 2009
19759015 Structure and interdomain dynamics of apoptosis-associated speck-like protein containing a CARD (ASC). External de Alba, E. J Biol Chem 2009
19679662 Identification of critical residues of the MyD88 death domain involved in the recruitment of downstream kinases. External Loiarro, M., Gallo, G., Fanto, N., De Santis, R., Carminati, P., Ruggiero, V., Sette, C. J Biol Chem 2009
19592493 An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4. External Motshwene, P. G., Moncrieffe, M. C., Grossmann, J. G., Kao, C., Ayaluru, M., Sandercock, A. M., Robinson, C. V., Latz, E., Gay, N. J. J Biol Chem 2009
19538180 Generation and functional characterization of a BCL10-inhibitory peptide that represses NF-kappaB activation. External Marasco, D., Stilo, R., Sandomenico, A., Monti, S. M., Tizzano, B., de Capua, A., Varricchio, E., Liguoro, D., Zotti, T., Formisano, S., Ruvo, M., Vito, P. Biochem J 2009
19524513 Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. External Cho, Y. S., Challa, S., Moquin, D., Genga, R., Ray, T. D., Guildford, M., Chan, F. K. Cell 2009
19524512 Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. External He, S., Wang, L., Miao, L., Wang, T., Du, F., Zhao, L., Wang, X. Cell 2009
19494828 The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer. External Malladi, S., Challa-Malladi, M., Fearnhead, H. O., Bratton, S. B. EMBO J 2009
19464198 Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. External Bertrand, M. J., Doiron, K., Labbe, K., Korneluk, R. G., Barker, P. A., Saleh, M. Immunity 2009
19444310 COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation. External Welteke, V., Eitelhuber, A., Duwel, M., Schweitzer, K., Naumann, M., Krappmann, D. EMBO Rep 2009
19427028 Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. External Jin, Z., Li, Y., Pitti, R., Lawrence, D., Pham, V. C., Lill, J. R., Ashkenazi, A. Cell 2009
19401709 Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury. External de Rivero Vaccari, J. P., Lotocki, G., Alonso, O. F., Bramlett, H. M., Dietrich, W. D., Keane, R. W. J Cereb Blood Flow Metab 2009
19337385 Evaluation of Nod-like receptor (NLR) effector domain interactions. External Wagner, R. N., Proell, M., Kufer, T. A., Schwarzenbacher, R. PLoS One 2009
19167362 Contribution of globular death domains and unstructured linkers to MyD88.IRAK-4 heterodimer formation: an explanation for the antagonistic activity of MyD88s. External Mendoza-Barbera, E., Corral-Rodriguez, M. A., Soares-Schanoski, A., Velarde, M., Macieira, S., Messerschmidt, A., Lopez-Collazo, E., Fuentes-Prior, P. Biochem Biophys Res Commun 2009
19166926 Regulation of IRAK-1 activation by its C-terminal domain. External Nguyen, T., De Nardo, D., Masendycz, P., Hamilton, J. A., Scholz, G. M. Cell Signal 2009
19158676 AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. External Fernandes-Alnemri, T., Yu, J. W., Datta, P., Wu, J., Alnemri, E. S. Nature 2009
19158675 AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. External Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., Fitzgerald, K. A. Nature 2009
19118384 The Fas-FADD death domain complex structure unravels signalling by receptor clustering. External Scott, F. L., Stec, B., Pop, C., Dobaczewska, M. K., Lee, J. J., Monosov, E., Robinson, H., Salvesen, G. S., Schwarzenbacher, R., Riedl, S. J. Nature 2009
19066616 Inhibition of the inflammasome complex reduces the inflammatory response after thromboembolic stroke in mice. External Abulafia, D. P., de Rivero Vaccari, J. P., Lozano, J. D., Lotocki, G., Keane, R. W., Dietrich, W. D. J Cereb Blood Flow Metab 2009
19060883 ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. External Oshima, S., Turer, E. E., Callahan, J. A., Chai, S., Advincula, R., Barrera, J., Shifrin, N., Lee, B., Benedict Yen, T. S., Woo, T., Malynn, B. A., Ma, A. Nature 2009
19036819 MAVS dimer is a crucial signaling component of innate immunity and the target of hepatitis C virus NS3/4A protease. External Baril, M., Racine, M. E., Penin, F., Lamarre, D. J Virol 2009
18939944 Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1). External Blankenship, J. W., Varfolomeev, E., Goncharov, T., Fedorova, A. V., Kirkpatrick, D. S., Izrael-Tomasevic, A., Phu, L., Arnott, D., Aghajan, M., Zobel, K., Bazan, J. F., Fairbrother, W. J., Deshayes, K., Vucic, D. Biochem J 2009
18845684 The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats. External Niizuma, K., Endo, H., Nito, C., Myer, D. J., Kim, G. S., Chan, P. H. Proc Natl Acad Sci U S A 2008
18802088 Distinct regulation of integrin-dependent T cell conjugate formation and NF-kappa B activation by the adapter protein ADAP. External Burbach, B. J., Srivastava, R., Medeiros, R. B., O'Gorman, W. E., Peterson, E. J., Shimizu, Y. J Immunol 2008
18775659 MEKK4 sequesters RIP2 to dictate NOD2 signal specificity. External Clark, N. M., Marinis, J. M., Cobb, B. A., Abbott, D. W. Curr Biol 2008
18641653 The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors. External Pobezinskaya, Y. L., Kim, Y. S., Choksi, S., Morgan, M. J., Li, T., Liu, C., Liu, Z. Nat Immunol 2008
18625728 The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association. External McCully, R. R., Pomerantz, J. L. Mol Cell Biol 2008
18524972 Threonine 66 in the death domain of IRAK-1 is critical for interaction with signaling molecules but is not a target site for autophosphorylation. External Neumann, D., Kollewe, C., Pich, A., Cao, P., Resch, K., Martin, M. U. J Leukoc Biol 2008
18511561 A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. External Hsu, L. C., Ali, S. R., McGillivray, S., Tseng, P. H., Mariathasan, S., Humke, E. W., Eckmann, L., Powell, J. J., Nizet, V., Dixit, V. M., Karin, M. Proc Natl Acad Sci U S A 2008
18485876 TNF-alpha induces two distinct caspase-8 activation pathways. External Wang, L., Du, F., Wang, X. Cell 2008
18362139 Mapping of POP1-binding site on pyrin domain of ASC. External Srimathi, T., Robbins, S. L., Dubas, R. L., Chang, H., Cheng, H., Roder, H., Park, Y. C. J Biol Chem 2008
18332441 Confinement of caspase-12 proteolytic activity to autoprocessing. External Roy, S., Sharom, J. R., Houde, C., Loisel, T. P., Vaillancourt, J. P., Shao, W., Saleh, M., Nicholson, D. W. Proc Natl Acad Sci U S A 2008
18328427 Yes and PI3K bind CD95 to signal invasion of glioblastoma. External Kleber, S., Sancho-Martinez, I., Wiestler, B., Beisel, A., Gieffers, C., Hill, O., Thiemann, M., Mueller, W., Sykora, J., Kuhn, A., Schreglmann, N., Letellier, E., Zuliani, C., Klussmann, S., Teodorczyk, M., Grone, H. J., Ganten, T. M., Sultmann, H., Tuttenberg, J., von Deimling, A., Regnier-Vigouroux, A., Herold-Mende, C., Martin-Villalba, A. Cancer Cell 2008
18086859 IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells. External Shinohara, H., Maeda, S., Watarai, H., Kurosaki, T. J Exp Med 2007
17962807 A cell cycle regulatory network controlling NF-kappaB subunit activity and function. External Barre, B., Perkins, N. D. EMBO J 2007
17920759 Constitutive association of MyD88 to IRAK in HTLV-I-transformed T cells. External Mizobe, T., Tsukada, J., Higashi, T., Mouri, F., Matsuura, A., Tanikawa, R., Minami, Y., Yoshida, Y., Tanaka, Y. Exp Hematol 2007
17692826 Evidence that genetic deletion of the TNF receptor p60 or p80 inhibits Fas mediated apoptosis in macrophages. External Takada, Y., Sung, B., Sethi, G., Chaturvedi, M. M., Aggarwal, B. B. Biochem Pharmacol 2007
17585340 LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization. External Poh, T. W., Huang, S., Hirpara, J. L., Pervaiz, S. Cell Death Differ 2007
17510469 Apolipoprotein E interrupts interleukin-1beta signaling in vascular smooth muscle cells. External Kawamura, A., Baitsch, D., Telgmann, R., Feuerborn, R., Weissen-Plenz, G., Hagedorn, C., Saku, K., Brand-Herrmann, S. M., von Eckardstein, A., Assmann, G., Nofer, J. R. Arterioscler Thromb Vasc Biol 2007
17486093 The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. External Hara, H., Ishihara, C., Takeuchi, A., Imanishi, T., Xue, L., Morris, S. W., Inui, M., Takai, T., Shibuya, A., Saijo, S., Iwakura, Y., Ohno, N., Koseki, H., Yoshida, H., Penninger, J. M., Saito, T. Nat Immunol 2007
17483456 Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling. External Duncan, J. A., Bergstralh, D. T., Wang, Y., Willingham, S. B., Ye, Z., Zimmermann, A. G., Ting, J. P. Proc Natl Acad Sci U S A 2007
17478723 Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1. External Medeiros, R. B., Burbach, B. J., Mueller, K. L., Srivastava, R., Moon, J. J., Highfill, S., Peterson, E. J., Shimizu, Y. Science 2007
17418785 Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. External Bruey, J. M., Bruey-Sedano, N., Luciano, F., Zhai, D., Balpai, R., Xu, C., Kress, C. L., Bailly-Maitre, B., Li, X., Osterman, A., Matsuzawa, S., Terskikh, A. V., Faustin, B., Reed, J. C. Cell 2007
17377159 NALP1 in vitiligo-associated multiple autoimmune disease. External Jin, Y., Mailloux, C. M., Gowan, K., Riccardi, S. L., LaBerge, G., Bennett, D. C., Fain, P. R., Spritz, R. A. N Engl J Med 2007
17354266 Autosomal dominant anhidrotic ectodermal dysplasias at the EDARADD locus. External Bal, E., Baala, L., Cluzeau, C., El Kerch, F., Ouldim, K., Hadj-Rabia, S., Bodemer, C., Munnich, A., Courtois, G., Sefiani, A., Smahi, A. Hum Mutat 2007
17349957 Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. External Faustin, B., Lartigue, L., Bruey, J. M., Luciano, F., Sergienko, E., Bailly-Maitre, B., Volkmann, N., Hanein, D., Rouiller, I., Reed, J. C. Mol Cell 2007
17339483 Pyrin-only protein 2 modulates NF-kappaB and disrupts ASC:CLR interactions. External Bedoya, F., Sandler, L. L., Harton, J. A. J Immunol 2007
17329820 Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD. External Park, H. H., Wu, H. Acta Crystallogr Sect F Struct Biol Cryst Commun 2007
17289572 Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. External Park, H. H., Logette, E., Raunser, S., Cuenin, S., Walz, T., Tschopp, J., Wu, H. Cell 2007
17276401 The death domain of IRAK-1: an oligomerization domain mediating interactions with MyD88, Tollip, IRAK-1, and IRAK-4. External Neumann, D., Kollewe, C., Resch, K., Martin, M. U. Biochem Biophys Res Commun 2007
17178784 Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation. External Dorfleutner, A., Bryan, N. B., Talbott, S. J., Funya, K. N., Rellick, S. L., Reed, J. C., Shi, X., Rojanasakul, Y., Flynn, D. C., Stehlik, C. Infect Immun 2007
17159907 Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling. External Feig, C., Tchikov, V., Schutze, S., Peter, M. E. EMBO J 2007
17159900 Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. External Tinel, A., Janssens, S., Lippens, S., Cuenin, S., Logette, E., Jaccard, B., Quadroni, M., Tschopp, J. EMBO J 2007
17054981 Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK. External Manon, F., Favier, A., Nunez, G., Simorre, J. P., Cusack, S. J Mol Biol 2007
17020950 RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2. External Komuro, A., Horvath, C. M. J Virol 2006
16980609 Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. External Merino, D., Lalaoui, N., Morizot, A., Schneider, P., Solary, E., Micheau, O. Mol Cell Biol 2006
16919273 Evidence of tumor necrosis factor receptor 1 signaling in human temporal lobe epilepsy. External Yamamoto, A., Schindler, C. K., Murphy, B. M., Bellver-Estelles, C., So, N. K., Taki, W., Meller, R., Simon, R. P., Henshall, D. C. Exp Neurol 2006
16818229 Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation. External Wegener, E., Oeckinghaus, A., Papadopoulou, N., Lavitas, L., Schmidt-Supprian, M., Ferch, U., Mak, T. W., Ruland, J., Heissmeyer, V., Krappmann, D. Mol Cell 2006
16809782 Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation. External Ishiguro, K., Green, T., Rapley, J., Wachtel, H., Giallourakis, C., Landry, A., Cao, Z., Lu, N., Takafumi, A., Goto, H., Daly, M. J., Xavier, R. J. Mol Cell Biol 2006
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16625199 Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. External Saleh, M., Mathison, J. C., Wolinski, M. K., Bensinger, S. J., Fitzgerald, P., Droin, N., Ulevitch, R. J., Green, D. R., Nicholson, D. W. Nature 2006
16611992 Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1. External Zheng, L., Bidere, N., Staudt, D., Cubre, A., Orenstein, J., Chan, F. K., Lenardo, M. Mol Cell Biol 2006
16585594 ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions. External Sarkar, A., Duncan, M., Hart, J., Hertlein, E., Guttridge, D. C., Wewers, M. D. J Immunol 2006
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16177806 Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. External Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R., Tschopp, J. Nature 2005
16127453 IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. External Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., Akira, S. Nat Immunol 2005
16037825 Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. External Yu, J. W., Wu, J., Zhang, Z., Datta, P., Ibrahimi, I., Taniguchi, S., Sagara, J., Fernandes-Alnemri, T., Alnemri, E. S. Cell Death Differ 2006
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16006552 A mechanism for death receptor discrimination by death adaptors. External Sandu, C., Gavathiotis, E., Huang, T., Wegorzewska, I., Werner, M. H. J Biol Chem 2005
15905496 Cutting edge: expression of IL-1 receptor-associated kinase-4 (IRAK-4) proteins with mutations identified in a patient with recurrent bacterial infections alters normal IRAK-4 interaction with components of the IL-1 receptor complex. External Medvedev, A. E., Thomas, K., Awomoyi, A., Kuhns, D. B., Gallin, J. I., Li, X., Vogel, S. N. J Immunol 2005
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15637807 Inhibition of Bcl10-mediated activation of NF-kappa B by BinCARD, a Bcl10-interacting CARD protein. External Woo, H. N., Hong, G. S., Jun, J. I., Cho, D. H., Choi, H. W., Lee, H. J., Chung, C. W., Kim, I. K., Jo, D. G., Pyo, J. O., Bertin, J., Jung, Y. K. FEBS Lett 2004
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15456791 PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages. External Bruey, J. M., Bruey-Sedano, N., Newman, R., Chandler, S., Stehlik, C., Reed, J. C. J Biol Chem 2004
15452120 The C-terminal tails of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas receptors have opposing functions in Fas-associated death domain (FADD) recruitment and can regulate agonist-specific mechanisms of receptor activation. External Thomas, L. R., Johnson, R. L., Reed, J. C., Thorburn, A. J Biol Chem 2004
15383541 INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. External Lamkanfi, M., Denecker, G., Kalai, M., D'hondt, K., Meeus, A., Declercq, W., Saelens, X., Vandenabeele, P. J Biol Chem 2004
15383280 Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. External Nam, Y. J., Mani, K., Ashton, A. W., Peng, C. F., Krishnamurthy, B., Hayakawa, Y., Lee, P., Korsmeyer, S. J., Kitsis, R. N. Mol Cell 2004
15253891 Taurine inhibits apoptosis by preventing formation of the Apaf-1/caspase-9 apoptosome. External Takatani, T., Takahashi, K., Uozumi, Y., Shikata, E., Yamamoto, Y., Ito, T., Matsuda, T., Schaffer, S. W., Fujio, Y., Azuma, J. Am J Physiol Cell Physiol 2004
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15173180 Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD. External Thomas, L. R., Henson, A., Reed, J. C., Salsbury, F. R., Thorburn, A. J Biol Chem 2004
15096476 PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1. External Wang, Y., Hasegawa, M., Imamura, R., Kinoshita, T., Kondo, C., Konaka, K., Suda, T. Int Immunol 2004
15073321 The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. External Tinel, A., Tschopp, J. Science 2004
15048887 Death-associated protein kinase expression in human temporal lobe epilepsy. External Henshall, D. C., Schindler, C. K., So, N. K., Lan, J. Q., Meller, R., Simon, R. P. Ann Neurol 2004
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Total 311 articles.