Death Domain (DD) superfamily

Family Name Disease
CARD Apaf1
CARD ASC
CARD Bcl-10 Colonic carcinoma, Follicular lymphoma, Germ cell tumor, MALT lymphoma, Mesothelioma, Sezary syndrome, T cell acute lymphocytic leukemia
CARD BinCARD
CARD CARD6
CARD CARD8
CARD CARD9 Chronic mucocutaneous candidiasis
CARD CARD10
CARD CARD11
CARD CARD12
CARD CARD14
CARD CARD16
CARD CARD17
CARD CARD18
CARD Caspase1
CARD Caspase2
CARD Caspase4
CARD Caspase5
CARD Caspase9
CARD Caspase12 Sepsis
CARD CIAP1
CARD CIAP2
CARD DLG5
CARD MAVS
CARD MDA5
CARD NLRP1 Vitiligo associated multiple autoimmune disease (VAMAS1)
CARD NOD1
CARD NOD2 Blau syndrome, Crohn's disease, Early onset sarcoidosis, Psoriatic arthritis
CARD NOL3
CARD QRICH1
CARD RAIDD
CARD RIG-1
CARD RIPK2
DD ANK1 Spherocytosis
DD ANK2 Cardiac arrhythmia
DD ANK3
DD ANKDD1A
DD ANKDD1B
DD DAPK1
DD DR3
DD DR4
DD DR5 Squamous cell carcinoma (SCC)
DD DR6
DD DTHD1
DD EDAR Ectodermal dysplasia, Hair thickness
DD EDARADD Ectodermal dysplasia
DD FADD Infections, recurrent with encephalopathy, hepatic dysfunction and cardiovasuclar malforamtions
DD Fas Autoimmune lymphoproliferative syndrome (ALPS), Lung cancer, Squamous cell carcinoma (SCC)
DD IRAK1
DD IRAK2
DD IRAK3 Asthma susceptivility
DD IRAK4 Invasive pneumococcal disease, Irak4 deficiency
DD MADD
DD MALT1
DD Myd88 Myd88 deficiency
DD NF-kB1
DD NF-kB2
DD NGFR
DD PIDD
DD RAIDD
DD RIP
DD THOC1
DD TNFR1 Tumor necrosis factor receptor-associated periodic syndrome (TRAPS)
DD TNFRSF11B Paget disease
DD TRADD
DD UNC5A
DD UNC5B
DD UNC5C
DD UNC5CL
DD UNC5D
DED Caspase8 Breast cancer, Caspase8 deficiency, Hepatocellualr carcinoma, Lung, Esophageal, Gastric, Colorectal, Cervical, Breast cancer
DED Caspase10 Autoimmune lymphoproliferative syndrome (ALPS), Gastric cancer, Non-hodgkin lymphoma
DED DEDD
DED DEDD2
DED FADD Infections, recurrent with encephalopathy, hepatic dysfunction and cardiovasuclar malforamtions
DED FLIP
DED PEA15
PYD POP1
PYD POP2
PYD AIM2
PYD ASC
PYD IFI16
PYD MNDA
PYD NLRP1 Vitiligo associated multiple autoimmune disease (VAMAS1)
PYD NLRP2
PYD NLRP3 CINCA syndrome, Familial cold autoinflammatory syndrome, Muckle-wells syndrome
PYD NLRP4
PYD NLRP5
PYD NLRP6
PYD NLRP7 Hydatidiform mole
PYD NLRP8
PYD NLRP9
PYD NLRP10
PYD NLRP11
PYD NLRP12 Familial cold autoinflammatory syndrome
PYD NLRP13
PYD NLRP14
PYD PYHIN1
PYD Pyrin Familial mediterranean fever